Protein name:
Caspase-7 (CASP-7) ;
Alternative:
CMH-1 ;Apoptotic protease Mch-3 ;ICE-like apoptotic protease 3 (ICE-LAP3) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit.
Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MADDQGCIEE | QGVEDSANED | SVDAKPDRSS | FVPSLFSKKK | KNVTMRSIKT |
100:
TRDRVPTYQY | NMNFEKLGKC | IIINNKNFDK | VTGMGVRNGT | DKDAEALFKC |
150:
FRSLGFDVIV | YNDCSCAKMQ | DLLKKASEED | HTNAACFACI | LLSHGEENVI |
200:
YGKDGVTPIK | DLTAHFRGDR | CKTLLEKPKL | FFIQACRGTE | LDDGIQADSG |
250:
PINDTDANPR | YKIPVEADFL | FAYSTVPGYY | SWRSPGRGSW | FVQALCSILE |
300:
EHGKDLEIMQ | ILTRVNDRVA | RHFESQSDDP | HFHEKKQIPC | VVSMLTKELY |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human CASP-7
ELISA Kit for Human CASP-7
CLIA Kit for Human CASP-7
CLIA Kit for Human CASP-7
Polyclonal Antibody for Human CASP-7
Polyclonal Antibody for Human CASP-7
Monoclonal Antibody for Human CASP-7
Monoclonal Antibody for Human CASP-7
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Mch3, a novel human apoptotic cysteine protease highly related to CPP32."
Fernandes-Alnemri T.
,
Takahashi A.
,
Armstrong R.C.
,
Krebs J.
,
Fritz L.C.
,
Tomaselli K.J.
,
Wang L.
,
Yu Z.
,
Croce C.M.
,
Salveson G.
,
Earnshaw W.C.
,
Litwack G.
,
Alnemri E.S.
Cancer Res.55:6045-6052(1995)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA)
tissue :
T-cell .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA)
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA)
tissue :
Spleen .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND ALPHA')
tissue :
Fetal lung .
tissue :
Fetal spleen .
5.
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N.
,
Chen X.
,
Rolfs A.
,
Halleck A.
,
Hines L.
,
Eisenstein S.
,
Koundinya M.
,
Raphael J.
,
Moreira D.
,
Kelley T.
,
LaBaer J.
,
Lin Y.
,
Phelan M.
,
Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA);VARIANT GLU-4
6.
"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N.
,
Kawamura Y.
,
Fukumoto A.
,
Miura A.
,
Honma R.
,
Satoh R.
,
Wakamatsu A.
,
Yamamoto J.
,
Kimura K.
,
Nishikawa T.
,
Andoh T.
,
Iida Y.
,
Ishikawa K.
,
Ito E.
,
Kagawa N.
,
Kaminaga C.
,
Kanehori K.
,
Kawakami B.
,
Kenmochi K.
,
Kimura R.
,
Kobayashi M.
,
Kuroita T.
,
Kuwayama H.
,
Maruyama Y.
,
Matsuo K.
,
Minami K.
,
Mitsubori M.
,
Mori M.
,
Morishita R.
,
Murase A.
,
Nishikawa A.
,
Nishikawa S.
,
Okamoto T.
,
Sakagami N.
,
Sakamoto Y.
,
Sasaki Y.
,
Seki T.
,
Sono S.
,
Sugiyama A.
,
Sumiya T.
,
Takayama T.
,
Takayama Y.
,
Takeda H.
,
Togashi T.
,
Yahata K.
,
Yamada H.
,
Yanagisawa Y.
,
Endo Y.
,
Imamoto F.
,
Kisu Y.
,
Tanaka S.
,
Isogai T.
,
Imai J.
,
Watanabe S.
,
Nomura N.
more...
Nat. Methods5:1011-1017(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA')
7.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
8.
"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P.
,
Earthrowl M.E.
,
Grafham D.V.
,
Rubenfield M.
,
French L.
,
Steward C.A.
,
Sims S.K.
,
Jones M.C.
,
Searle S.
,
Scott C.
,
Howe K.
,
Hunt S.E.
,
Andrews T.D.
,
Gilbert J.G.R.
,
Swarbreck D.
,
Ashurst J.L.
,
Taylor A.
,
Battles J.
,
Bird C.P.
,
Ainscough R.
,
Almeida J.P.
,
Ashwell R.I.S.
,
Ambrose K.D.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Banerjee R.
,
Bates K.
,
Beasley H.
,
Bray-Allen S.
,
Brown A.J.
,
Brown J.Y.
,
Burford D.C.
,
Burrill W.
,
Burton J.
,
Cahill P.
,
Camire D.
,
Carter N.P.
,
Chapman J.C.
,
Clark S.Y.
,
Clarke G.
,
Clee C.M.
,
Clegg S.
,
Corby N.
,
Coulson A.
,
Dhami P.
,
Dutta I.
,
Dunn M.
,
Faulkner L.
,
Frankish A.
,
Frankland J.A.
,
Garner P.
,
Garnett J.
,
Gribble S.
,
Griffiths C.
,
Grocock R.
,
Gustafson E.
,
Hammond S.
,
Harley J.L.
,
Hart E.
,
Heath P.D.
,
Ho T.P.
,
Hopkins B.
,
Horne J.
,
Howden P.J.
,
Huckle E.
,
Hynds C.
,
Johnson C.
,
Johnson D.
,
Kana A.
,
Kay M.
,
Kimberley A.M.
,
Kershaw J.K.
,
Kokkinaki M.
,
Laird G.K.
,
Lawlor S.
,
Lee H.M.
,
Leongamornlert D.A.
,
Laird G.
,
Lloyd C.
,
Lloyd D.M.
,
Loveland J.
,
Lovell J.
,
McLaren S.
,
McLay K.E.
,
McMurray A.
,
Mashreghi-Mohammadi M.
,
Matthews L.
,
Milne S.
,
Nickerson T.
,
Nguyen M.
,
Overton-Larty E.
,
Palmer S.A.
,
Pearce A.V.
,
Peck A.I.
,
Pelan S.
,
Phillimore B.
,
Porter K.
,
Rice C.M.
,
Rogosin A.
,
Ross M.T.
,
Sarafidou T.
,
Sehra H.K.
,
Shownkeen R.
,
Skuce C.D.
,
Smith M.
,
Standring L.
,
Sycamore N.
,
Tester J.
,
Thorpe A.
,
Torcasso W.
,
Tracey A.
,
Tromans A.
,
Tsolas J.
,
Wall M.
,
Walsh J.
,
Wang H.
,
Weinstock K.
,
West A.P.
,
Willey D.L.
,
Whitehead S.L.
,
Wilming L.
,
Wray P.W.
,
Young L.
,
Chen Y.
,
Lovering R.C.
,
Moschonas N.K.
,
Siebert R.
,
Fechtel K.
,
Bentley D.
,
Durbin R.M.
,
Hubbard T.
,
Doucette-Stamm L.
,
Beck S.
,
Smith D.R.
,
Rogers J.
more...
Nature429:375-381(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA);VARIANT GLU-4
tissue :
Skin .
11.
"In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains."
Fernandes-Alnemri T.
,
Armstrong R.C.
,
Krebs J.F.
,
Srinivasula S.M.
,
Wang L.
,
Bullrich F.
,
Fritz L.C.
,
Trapani J.A.
,
Tomaselli K.J.
,
Litwack G.
,
Alnemri E.S.
Proc. Natl. Acad. Sci. U.S.A.93:7464-7469(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC PROCESSING
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BIRC6/BRUCE
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 51-303;SUBUNIT